Internetwork Packet Exchange (IPX) is the OSI-model Network layer protocol in the IPX/SPX protocol stack.
The IPX/SPX protocol stack is supported by Novell's NetWare network operating system. Because of Netware's popularity through the late 1980s into the mid 1990s, IPX became a popular internetworking protocol. Novell derived IPX from Xerox Network Services' IDP protocol.
IPX usage is in general decline as the boom of the Internet has made TCP/IP nearly universal. Computers and networks can run multiple network protocols, so almost all IPX sites will be running TCP/IP as well to allow for Internet connectivity. It is also now possible to run Novell products without IPX, as they have supported both IPX and TCP/IP since NetWare reached version 5.
Reference:
http://en.wikipedia.org/wiki/Ipx